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( A, B ) Alterations of H3K4me3 ( A ) and H3K27me3 ( B ) peaks between JIMT1 and SKBR3. ( C ) Different abundance of H3K4me3 and H3K27me3 at SLC7A11 promoter regions in JIMT1 and SKBR3. ( D ) Decreased <t>ASH2L</t> inhibited total H3K4me3 expression. ( E ) Decreased ASH2L inhibited SLC7A11 expression. ( F ) Decreased ASH2L suppressed H3K4me3 expression at SLC7A11 promoter regions. ( G ) Decreased ASH2L suppressed cystine uptake ability. ( H ) Decreased ASH2L induced lipid peroxidation and ferroptosis. Significances were determined by two-tailed unpaired t-test ( F–H ). ns, p≥0.05; *p<0.05; **p<0.01; ***p<0.001. Figure 5—source data 1. PDF file containing original western blots for , indicating relevant bands. Figure 5—source data 2. Original files for western blot analysis displayed in . Figure 5—source data 3. Raw data files for .
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ash2l  (Bethyl)
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( A, B ) Alterations of H3K4me3 ( A ) and H3K27me3 ( B ) peaks between JIMT1 and SKBR3. ( C ) Different abundance of H3K4me3 and H3K27me3 at SLC7A11 promoter regions in JIMT1 and SKBR3. ( D ) Decreased <t>ASH2L</t> inhibited total H3K4me3 expression. ( E ) Decreased ASH2L inhibited SLC7A11 expression. ( F ) Decreased ASH2L suppressed H3K4me3 expression at SLC7A11 promoter regions. ( G ) Decreased ASH2L suppressed cystine uptake ability. ( H ) Decreased ASH2L induced lipid peroxidation and ferroptosis. Significances were determined by two-tailed unpaired t-test ( F–H ). ns, p≥0.05; *p<0.05; **p<0.01; ***p<0.001. Figure 5—source data 1. PDF file containing original western blots for , indicating relevant bands. Figure 5—source data 2. Original files for western blot analysis displayed in . Figure 5—source data 3. Raw data files for .
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anti ash2l  (Bethyl)
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( A, B ) Alterations of H3K4me3 ( A ) and H3K27me3 ( B ) peaks between JIMT1 and SKBR3. ( C ) Different abundance of H3K4me3 and H3K27me3 at SLC7A11 promoter regions in JIMT1 and SKBR3. ( D ) Decreased <t>ASH2L</t> inhibited total H3K4me3 expression. ( E ) Decreased ASH2L inhibited SLC7A11 expression. ( F ) Decreased ASH2L suppressed H3K4me3 expression at SLC7A11 promoter regions. ( G ) Decreased ASH2L suppressed cystine uptake ability. ( H ) Decreased ASH2L induced lipid peroxidation and ferroptosis. Significances were determined by two-tailed unpaired t-test ( F–H ). ns, p≥0.05; *p<0.05; **p<0.01; ***p<0.001. Figure 5—source data 1. PDF file containing original western blots for , indicating relevant bands. Figure 5—source data 2. Original files for western blot analysis displayed in . Figure 5—source data 3. Raw data files for .
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Image Search Results


( A, B ) Alterations of H3K4me3 ( A ) and H3K27me3 ( B ) peaks between JIMT1 and SKBR3. ( C ) Different abundance of H3K4me3 and H3K27me3 at SLC7A11 promoter regions in JIMT1 and SKBR3. ( D ) Decreased ASH2L inhibited total H3K4me3 expression. ( E ) Decreased ASH2L inhibited SLC7A11 expression. ( F ) Decreased ASH2L suppressed H3K4me3 expression at SLC7A11 promoter regions. ( G ) Decreased ASH2L suppressed cystine uptake ability. ( H ) Decreased ASH2L induced lipid peroxidation and ferroptosis. Significances were determined by two-tailed unpaired t-test ( F–H ). ns, p≥0.05; *p<0.05; **p<0.01; ***p<0.001. Figure 5—source data 1. PDF file containing original western blots for , indicating relevant bands. Figure 5—source data 2. Original files for western blot analysis displayed in . Figure 5—source data 3. Raw data files for .

Journal: eLife

Article Title: Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

doi: 10.7554/eLife.103953

Figure Lengend Snippet: ( A, B ) Alterations of H3K4me3 ( A ) and H3K27me3 ( B ) peaks between JIMT1 and SKBR3. ( C ) Different abundance of H3K4me3 and H3K27me3 at SLC7A11 promoter regions in JIMT1 and SKBR3. ( D ) Decreased ASH2L inhibited total H3K4me3 expression. ( E ) Decreased ASH2L inhibited SLC7A11 expression. ( F ) Decreased ASH2L suppressed H3K4me3 expression at SLC7A11 promoter regions. ( G ) Decreased ASH2L suppressed cystine uptake ability. ( H ) Decreased ASH2L induced lipid peroxidation and ferroptosis. Significances were determined by two-tailed unpaired t-test ( F–H ). ns, p≥0.05; *p<0.05; **p<0.01; ***p<0.001. Figure 5—source data 1. PDF file containing original western blots for , indicating relevant bands. Figure 5—source data 2. Original files for western blot analysis displayed in . Figure 5—source data 3. Raw data files for .

Article Snippet: Primary antibodies included SLC7A11 (CST, 12691 S), GPX4 (CST, 52455 S), glutathione synthetase (Abcam, ab124811), glutathione reductase (Abcam, ab124995), ASH2L (CST, 5019T), H3K4me3 (Abcam, ab213224), GAPDH (proteintech, HRP-60004), and H3 (Abcam, ab1791).

Techniques: Expressing, Two Tailed Test, Western Blot